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Wellness Molecular

Full interpretation of a PCR panel result

Organisms, resistance determinants, coverage, polymicrobial planning, dosing, interactions and warnings, on one report the prescriber can act on.

What you send

  • The organisms and resistance markers your panel detected
  • The specimen type and how it was collected
  • Date of birth and collection date (the report computes age at collection itself)
  • Optional: allergies on file, pregnancy, weight for pediatric dosing

Incomplete data is confirmed with you, never guessed. An organism, gene or allergy the engine does not recognize, or dates that disagree, come straight back for correction. No report is produced on a guess.

Specimen sources

  • Urine
  • Wound
  • Respiratory
  • Stool
  • Genital
  • Blood
  • Cerebrospinal fluid
  • Tissue
  • Skin
  • Nail

What comes back

A ranked plan
The lead agent with dose, route and duration, then ranked alternatives, each dosed. Two plans where the presentation calls for two.
Coverage, organism by organism
For every option, which detected organisms it covers, which it does not, and which depend on susceptibility.
Resistance, read for what it does
What each detected gene rules out and what it leaves open, including the genes that change nothing and the organisms whose own biology rules drugs out.
The six safety checks
Allergy, boxed warnings, interactions, age, pregnancy and organ function, with the action printed beside each finding.
Whether to treat at all
Colonization versus infection, asymptomatic carriage, specimen quality and the criteria for treating, stated before any drug is.
The reasoning, written down
Plain sentences the prescriber can check, each tied to something detected on this specimen, each traced to an authoritative U.S. source.

The report names what the assay cannot distinguish. Where a plan depends on susceptibility the panel cannot measure, it says so, and it writes down the step-down to take once culture returns.

What it does

Interpretation, not a gene list

A case from our sample reports: an 84-year-old man, urine, Klebsiella pneumoniae with an ESBL gene detected, and a documented penicillin allergy.

What a result report gives you

Klebsiella pneumoniae
Extended-spectrum beta-lactamase
Allergy on file: penicillin

Accurate, and it leaves every decision open:

  • Is ceftriaxone still reasonable? (No.)
  • Which carbapenem, and is a carbapenem even needed here?
  • Does the penicillin allergy rule out carbapenems too?
  • Is this bladder-confined or not, and what dose and duration follow from that?

What the engine gives you

Ertapenem

1 g IV/IM once daily · 7 days if clinically improving

  • ESBL detected: cephalosporins and aztreonam are expected to fail. Stated plainly, not left to inference.
  • Ertapenem, not meropenem. Meropenem stays in reserve for severe disease.
  • Penicillin allergy: carbapenem cross-reactivity is low, so it is flagged to verify tolerability rather than removed outright.
  • No assumption that a man's UTI is complicated. The report names what the assay cannot distinguish, and when to treat him as uncomplicated.
  • Ranked alternatives follow, each with its own dose.
Open this report

Resistance, read for what it does

A gene result is not a verdict

Some resistance comes from losing a function, some from gaining one, and some genes defeat only part of a drug. The engine reads every gene for what it actually does.

Loss of function

Some genes only matter when they break

Nitrofurantoin is switched on by the bacterium's own enzymes. Resistance comes from losing them, so finding the gene is not resistance, and a first-line bladder agent stays available.

In the sample report: nfsA detected, nitrofurantoin retained.

Loss of function

One broken enzyme, one lost drug

Isoniazid and pyrazinamide are also switched on by the organism. A mutation that disables one of those enzymes takes out that drug alone, not the rest of the tuberculosis regimen.

Gain of function

Some resistance switches on during treatment

Organisms such as Enterobacter carry a built-in enzyme that can ramp up once therapy starts. The report ranks down the drugs it defeats, even when the panel detects no gene at all.

Half a combination

Some genes defeat only half a drug

A sulfonamide-resistance gene compromises one half of trimethoprim-sulfamethoxazole. The report says which half, and what that does and does not rule out.

In the sample report: sul1 detected, TMP-SMX kept as the cystitis option.

A blank is not a green light. When the marker that matters for a recommended drug was not detected, the report says so, rather than letting silence read as susceptible.

Stewardship

Sometimes the right answer is no antibiotic

A stewardship tool that only ever recommends drugs is not a stewardship tool.

Supportive care, stated as the recommendation

Norovirus on a stool panel returns a supportive-care plan, with rehydration, diet, antiemetics and escalation signs, and states plainly that antibiotics are not indicated.

Open the norovirus report

Supportive stays supportive

Where no antimicrobial option exists, a rhinovirus, say, the report says so, and that this is not a reason to broaden therapy.

Maintenance

When guidance changes, so do we

Antimicrobial guidance moves every year. A report built on a superseded guideline still looks completely normal.

  • Current, or it does not ship

    Every recommendation traces to a named U.S. source. When a body archives a guideline, the rule is re-anchored or retired, never left standing because it still reads plausibly.

  • You hear it before your reports do

    Before a new engine version reaches your reports, your laboratory administrators get a notice in the portal and by e-mail saying what changes and when.

  • Nothing changes quietly

    Every change is recorded down to the rule and the source behind it, and we can show you that record.

Comparison

What sets it apart

Measured against a plain result report, and against interpretive reporting generally.

AspectBasic result reportInterpretive reporting, generallyWellness Reporting Suite
What arrivesOrganisms and genes detectedA suggested drug, sometimes a doseRanked plan with dose, route, duration and alternatives
ResistanceGene listedUsually narrativeWhat the gene rules out, which agents remain, coverage per organism
Basis for each recommendationNoneRarely disclosed per ruleHundreds of decision rules, each traced to published U.S. guidance and research
AI at report timeNot applicableOften not disclosed either wayNone: every recommendation comes from fixed rules, never from an AI model
Safety screeningNoneVariesAllergy, boxed warnings, label interactions, age, pregnancy, organ function
Incomplete dataReported as-isVariesConfirmed with you before we interpret it
Before it reaches youLab result reviewTypically noneScreened on the finished report; anything flagged is held until resolved
Charge on a correctionNot applicableOften re-billedNever. One accession is billed once, ever
Charge on a negativeUsually billedUsually billedNo charge for a true negative

The middle column describes the category in general, not any named provider.

Switching

Switching does not disrupt your workflow

The report arrives where your results already arrive. Nothing changes about how your staff orders or collects.